| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 4,183,385 | 4,020,831 | 462,849,716.4 | 0.1888 | 5.3751 | 09/30/2025 |
| 2 | Darwin Global Management Ltd. | 3,164,501 | 3,164,501 | 350,120,390.64 | 6.2521 | 4.066 | 09/30/2025 |
| 3 | Point72 Asset Management LP | 2,925,352 | 2,895,934 | 323,660,945.28 | 0.589 | 3.7587 | 09/30/2025 |
| 4 | Cormorant Asset Management LP | 1,950,000 | -180,000 | 215,748,000 | 11.7123 | 2.5055 | 09/30/2025 |
| 5 | Paradigm BioCapital Advisors LP | 1,564,196 | 1,564,196 | 173,062,645.44 | 3.99 | 2.0098 | 09/30/2025 |
| 6 | Caligan Partners LP | 1,451,924 | 182,805 | 160,640,871.36 | 17.4008 | 1.8655 | 09/30/2025 |
| 7 | Fidelity Management & Research Co. LLC | 1,430,673 | 1,430,673 | 158,289,660.72 | 0.0088 | 1.8382 | 09/30/2025 |
| 8 | Adar1 Capital Management LLC | 1,350,826 | -859,193 | 149,455,388.64 | 13.9601 | 1.7356 | 09/30/2025 |
| 9 | Octagon Capital Advisors LP | 1,325,000 | 95,000 | 146,598,000 | 16.6703 | 1.7025 | 09/30/2025 |
| 10 | Millennium Management LLC | 1,100,030 | 112,616 | 121,707,319.2 | 0.0948 | 1.4134 | 09/30/2025 |
| 11 | Vestal Point Capital LP | 1,000,000 | 1,000,000 | 110,640,000 | 3.98 | 1.2849 | 09/30/2025 |
| 12 | Adage Capital Management LP | 977,629 | 977,629 | 108,164,872.56 | 0.1641 | 1.2561 | 09/30/2025 |
| 13 | Baker Bros. Advisors LP | 875,796 | 875,796 | 96,898,069.44 | 0.4856 | 1.1253 | 09/30/2025 |
| 14 | Farallon Capital Management LLC | 805,000 | 805,000 | 89,065,200 | 0.4447 | 1.0343 | 09/30/2025 |
| 15 | Saturn V Capital Management LP | 801,224 | 248,298 | 88,647,423.36 | 14.446 | 1.0295 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Xtrackers SICAV - MSCI World Swap UCITS ETF | 764,899 | 764,899 | 84,628,425.36 | 0.7933 | 0.9828 | 11/28/2025 |
| 2 | abrdn World Healthcare Fund | 397,578 | -312,938 | 43,988,029.92 | 7.4097 | 0.5108 | 10/31/2025 |
| 3 | Eventide Healthcare & Life Sciences Fund | 396,904 | 396,904 | 43,913,458.56 | 2.5915 | 0.51 | 09/30/2025 |
| 4 | Fidelity Growth Company Commingled Pool | 374,807 | 374,807 | 41,468,646.48 | 0.0386 | 0.4816 | 10/31/2025 |
| 5 | Alger Institutional Funds - Focus Equity Fund | 314,786 | 314,786 | 34,827,923.04 | 0.788 | 0.4045 | 10/31/2025 |
| 6 | FTIF SICAV - Biotechnology Discovery Fund | 307,602 | -565,693 | 34,033,085.28 | 1.9249 | 0.3952 | 10/31/2025 |
| 7 | Fidelity Growth Company Fund | 298,473 | 298,473 | 33,023,052.72 | 0.0414 | 0.3835 | 10/31/2025 |
| 8 | Alger Funds II - Alger Spectra Fund | 258,451 | 258,451 | 28,595,018.64 | 0.6466 | 0.3321 | 10/31/2025 |
| 9 | FCP Medical - BioHealth | 201,222 | 201,222 | 22,263,202.08 | 2.3202 | 0.2585 | 09/30/2025 |
| 10 | Franklin Biotechnology Discovery Fund | 173,710 | -323,982 | 19,219,274.4 | 1.8597 | 0.2232 | 10/31/2025 |
| 11 | Alger Institutional Funds - Capital Appreciation Inst. Fund | 173,148 | 173,148 | 19,157,094.72 | 0.5907 | 0.2225 | 10/31/2025 |
| 12 | Alger Small Cap Focus Fund | 154,768 | 154,768 | 17,123,531.52 | 1.846 | 0.1989 | 10/31/2025 |
| 13 | Westfield Small/Mid Cap Growth Equity | 138,500 | 138,500 | 15,323,640 | 0.9338 | 0.178 | 10/31/2025 |
| 14 | Lord Abbett Developing Growth Fund | 138,439 | 138,439 | 15,316,890.96 | 0.6833 | 0.1779 | 07/31/2025 |
| 15 | Alger Capital Appreciation Fund | 128,898 | 128,898 | 14,261,274.72 | 0.5449 | 0.1656 | 10/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 4,183,385 | 4,020,831 | 462,849,716.4 | 0.1888 | 5.3751 | 09/30/2025 |
| 2 | Darwin Global Management Ltd. | 3,164,501 | 3,164,501 | 350,120,390.64 | 6.2521 | 4.066 | 09/30/2025 |
| 3 | Point72 Asset Management LP | 2,925,352 | 2,895,934 | 323,660,945.28 | 0.589 | 3.7587 | 09/30/2025 |
| 4 | Paradigm BioCapital Advisors LP | 1,564,196 | 1,564,196 | 173,062,645.44 | 3.99 | 2.0098 | 09/30/2025 |
| 5 | Fidelity Management & Research Co. LLC | 1,430,673 | 1,430,673 | 158,289,660.72 | 0.0088 | 1.8382 | 09/30/2025 |
| 6 | Vestal Point Capital LP | 1,000,000 | 1,000,000 | 110,640,000 | 3.98 | 1.2849 | 09/30/2025 |
| 7 | Adage Capital Management LP | 977,629 | 977,629 | 108,164,872.56 | 0.1641 | 1.2561 | 09/30/2025 |
| 8 | Baker Bros. Advisors LP | 875,796 | 875,796 | 96,898,069.44 | 0.4856 | 1.1253 | 09/30/2025 |
| 9 | Farallon Capital Management LLC | 805,000 | 805,000 | 89,065,200 | 0.4447 | 1.0343 | 09/30/2025 |
| 10 | Nationale-Nederlanden PTE SA | 731,523 | 731,523 | 80,935,704.72 | 0.5017 | 0.9399 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Deep Track Capital LP | 0 | -3,579,209 | 0 | 0 | 0 | |
| 2 | Great Point Partners LLC | 150,000 | -1,488,111 | 16,596,000 | 5.4203 | 0.1927 | 09/30/2025 |
| 3 | VHCP Management LLC | 0 | -998,570 | 0 | 0 | 0 | |
| 4 | Allostery Investments LP | 167,350 | -932,304 | 18,515,604 | 64.7881 | 0.215 | 06/30/2025 |
| 5 | Nantahala Capital Management LLC | 557,564 | -925,430 | 61,688,880.96 | 3.417 | 0.7164 | 09/30/2025 |
| 6 | JPMorgan Securities LLC (Investment Management) | 0 | -907,679 | 0 | 0 | 0 | |
| 7 | Adar1 Capital Management LLC | 1,350,826 | -859,193 | 149,455,388.64 | 13.9601 | 1.7356 | 09/30/2025 |
| 8 | Franklin Advisers, Inc. | 516,090 | -854,960 | 57,100,197.6 | 0.0252 | 0.6631 | 09/30/2025 |
| 9 | Citadel Advisors LLC | 516,679 | -812,931 | 57,165,364.56 | 0.062 | 0.6639 | 09/30/2025 |
| 10 | Kennedy Capital Management LLC | 0 | -225,191 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.