| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Cormorant Asset Management LP | 3,978,229 | 1,080,372 | 56,570,416.38 | 3.8231 | 6.7732 | 06/30/2026 |
| 2 | Balyasny Asset Management LP | 3,061,668 | 2,183,822 | 43,536,918.96 | 0.0832 | 5.2127 | 06/30/2026 |
| 3 | Point72 Asset Management LP | 2,140,664 | 2,140,664 | 30,440,242.08 | 0.0481 | 3.6446 | 06/30/2026 |
| 4 | Perceptive Advisors LLC | 1,793,190 | 1,793,190 | 25,499,161.8 | 0.4688 | 3.053 | 06/30/2026 |
| 5 | Casdin Capital LLC | 1,250,000 | 711,539 | 17,775,000 | 0.8752 | 2.1282 | 06/30/2026 |
| 6 | Adar1 Capital Management LLC | 1,017,805 | 899,896 | 14,473,187.1 | 0.7919 | 1.7329 | 06/30/2026 |
| 7 | Octagon Capital Advisors LP | 934,716 | 934,716 | 13,291,661.52 | 1.7122 | 1.5914 | 06/30/2026 |
| 8 | Millennium Management LLC | 807,832 | 126,057 | 11,487,371.04 | 0.0079 | 1.3754 | 06/30/2026 |
| 9 | Braidwell LP | 795,214 | 795,214 | 11,307,943.08 | 0.3995 | 1.3539 | 06/30/2026 |
| 10 | Squadron Capital Management LLC | 764,876 | -500,355 | 10,876,536.72 | 4.4097 | 1.3023 | 06/30/2026 |
| 11 | Eventide Asset Management LLC | 718,747 | 718,747 | 10,220,582.34 | 0.1482 | 1.2237 | 06/30/2026 |
| 12 | Superstring Capital Management LP | 552,501 | 137,649 | 7,856,564.22 | 4.7865 | 0.9407 | 06/30/2026 |
| 13 | Adage Capital Management LP | 538,461 | 0 | 7,656,915.42 | 0.0105 | 0.9168 | 06/30/2026 |
| 14 | Woodline Partners LP | 455,733 | 246,474 | 6,480,523.26 | 0.0201 | 0.7759 | 06/30/2026 |
| 15 | Soleus Capital Management LP (Investment Management) | 405,523 | 405,523 | 5,766,537.06 | 0.2161 | 0.6904 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Eventide Healthcare & Life Sciences Fund | 718,747 | 718,747 | 10,220,582.34 | 0.6544 | 1.2237 | 06/30/2026 |
| 2 | Tema Oncology ETF | 75,283 | 9,249 | 1,070,524.26 | 0.5327 | 0.1282 | 09/30/2026 |
| 3 | Virtus Biotech Clinical Trials ETF | 30,749 | 30,749 | 437,250.78 | 1.0689 | 0.0524 | 09/30/2026 |
| 4 | State Street SPDR S&P Emerging Markets Small Cap ETF | 29,000 | 29,000 | 412,380 | 0.0614 | 0.0494 | 09/30/2026 |
| 5 | Fidelity Nasdaq Composite Index Fund | 17,020 | 5,887 | 242,024.4 | 0.0008 | 0.029 | 08/31/2026 |
| 6 | State Street SPDR S&P China ETF | 7,200 | 7,200 | 102,384 | 0.0227 | 0.0123 | 09/30/2026 |
| 7 | BlackRock Strategic Fds. - Asia Pacific Div. Eq. Abs. Return | 1,728 | 1,728 | 24,572.16 | 0.0143 | 0.0029 | 07/31/2026 |
| 8 | ProFunds - UltraChina | 1,156 | 1,156 | 16,438.32 | 0.0883 | 0.002 | 07/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Balyasny Asset Management LP | 3,061,668 | 2,183,822 | 43,536,918.96 | 0.0832 | 5.2127 | 06/30/2026 |
| 2 | Point72 Asset Management LP | 2,140,664 | 2,140,664 | 30,440,242.08 | 0.0481 | 3.6446 | 06/30/2026 |
| 3 | Perceptive Advisors LLC | 1,793,190 | 1,793,190 | 25,499,161.8 | 0.4688 | 3.053 | 06/30/2026 |
| 4 | Cormorant Asset Management LP | 3,978,229 | 1,080,372 | 56,570,416.38 | 3.8231 | 6.7732 | 06/30/2026 |
| 5 | Octagon Capital Advisors LP | 934,716 | 934,716 | 13,291,661.52 | 1.7122 | 1.5914 | 06/30/2026 |
| 6 | Adar1 Capital Management LLC | 1,017,805 | 899,896 | 14,473,187.1 | 0.7919 | 1.7329 | 06/30/2026 |
| 7 | Braidwell LP | 795,214 | 795,214 | 11,307,943.08 | 0.3995 | 1.3539 | 06/30/2026 |
| 8 | Eventide Asset Management LLC | 718,747 | 718,747 | 10,220,582.34 | 0.1482 | 1.2237 | 06/30/2026 |
| 9 | Casdin Capital LLC | 1,250,000 | 711,539 | 17,775,000 | 0.8752 | 2.1282 | 06/30/2026 |
| 10 | Soleus Capital Management LP (Investment Management) | 405,523 | 405,523 | 5,766,537.06 | 0.2161 | 0.6904 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Squadron Capital Management LLC | 764,876 | -500,355 | 10,876,536.72 | 4.4097 | 1.3023 | 06/30/2026 |
| 2 | T. Rowe Price Associates, Inc. (IM) | 0 | -99,843 | 0 | 0 | 0 | |
| 3 | UBS Securities LLC | 52,895 | -69,366 | 752,166.9 | 0.0003 | 0.0901 | 06/30/2026 |
| 4 | Cantor Fitzgerald & Co. | 0 | -40,310 | 0 | 0 | 0 | |
| 5 | TD Asset Management, Inc. | 0 | -35,746 | 0 | 0 | 0 | |
| 6 | Persistent Asset Partners Ltd. | 0 | -33,732 | 0 | 0 | 0 | |
| 7 | Columbia Management Investment Advisers LLC | 86,700 | -33,456 | 1,232,874 | 0.0003 | 0.1476 | 06/30/2026 |
| 8 | Tidal Investments LLC | 44,354 | -21,680 | 630,713.88 | 0.0014 | 0.0755 | 06/30/2026 |
| 9 | Dymon Asia Capital (Singapore) Pte Ltd. | 0 | -15,000 | 0 | 0 | 0 | |
| 10 | Affinity Asset Advisors LLC | 153,847 | -10,901 | 2,187,704.34 | 0.141 | 0.2619 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.