| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Redmile Group LLC | 2,733,926 | 2,577,676 | 24,085,888.06 | 1.7121 | 5.5513 | 06/30/2026 |
| 2 | Cormorant Asset Management LP | 2,465,348 | 0 | 21,719,715.88 | 1.553 | 5.006 | 06/30/2026 |
| 3 | Federated Global Investment Management Corp. | 1,618,000 | 0 | 14,254,580 | 0.1254 | 3.2854 | 06/30/2026 |
| 4 | Nantahala Capital Management LLC | 1,568,188 | 368,188 | 13,815,736.28 | 0.8823 | 3.1843 | 06/30/2026 |
| 5 | Casdin Capital LLC | 1,550,000 | 0 | 13,655,500 | 0.6882 | 3.1473 | 06/30/2026 |
| 6 | Fidelity Management & Research Co. LLC | 1,458,677 | 0 | 12,850,944.37 | 0.0006 | 2.9619 | 06/30/2026 |
| 7 | abrdn, Inc. | 846,695 | 139,039 | 7,459,382.95 | 0.0694 | 1.7192 | 06/30/2026 |
| 8 | Perceptive Advisors LLC | 600,000 | 0 | 5,286,000 | 0.1011 | 1.2183 | 06/30/2026 |
| 9 | ALPS Advisors, Inc. | 49,984 | 49,984 | 440,359.04 | 0.0018 | 0.1015 | 06/30/2026 |
| 10 | Bellevue Asset Management AG | 49,248 | -752 | 433,874.88 | 0.0081 | 0.1 | 06/30/2026 |
| 11 | Seven Grand Managers LLC | 47,600 | -152,400 | 419,356 | 0.0195 | 0.0967 | 06/30/2026 |
| 12 | Sectoral Asset Management, Inc. | 43,500 | 0 | 383,235 | 0.2569 | 0.0883 | 06/30/2026 |
| 13 | Burkehill Global Management LP | 35,000 | 0 | 308,350 | 0.0126 | 0.0711 | 06/30/2026 |
| 14 | Quadrature Capital Ltd. | 20,461 | 20,461 | 180,261.41 | 0.0015 | 0.0415 | 06/30/2026 |
| 15 | Two Sigma Investments LP | 18,072 | 3,831 | 159,214.32 | 0.0001 | 0.0367 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Federated Hermes Kaufmann Fund | 981,184 | 0 | 8,644,231.04 | 0.1733 | 1.9923 | 06/30/2026 |
| 2 | Fidelity Growth Company Commingled Pool | 671,144 | -1,476,593 | 5,912,778.64 | 0.0044 | 1.3628 | 08/31/2026 |
| 3 | Federated Hermes Kaufmann Small Cap Fund | 615,708 | 0 | 5,424,387.48 | 0.1987 | 1.2502 | 06/30/2026 |
| 4 | Fidelity Growth Company Fund | 507,250 | -627 | 4,468,872.5 | 0.0044 | 1.03 | 08/31/2026 |
| 5 | abrdn Healthcare Investors | 463,275 | 463,275 | 4,081,452.75 | 0.3316 | 0.9407 | 09/30/2026 |
| 6 | abrdn World Healthcare Fund | 414,458 | 139,458 | 3,651,374.98 | 0.626 | 0.8416 | 08/31/2026 |
| 7 | abrdn Life Sciences Investors | 170,464 | 28,677 | 1,501,787.84 | 0.2775 | 0.3461 | 06/30/2026 |
| 8 | Fidelity Growth Company K6 Fund | 141,983 | -291 | 1,250,870.23 | 0.0043 | 0.2883 | 08/31/2026 |
| 9 | Fidelity Series Growth Company Fund | 129,200 | 0 | 1,138,252 | 0.0045 | 0.2623 | 08/31/2026 |
| 10 | Biotech Growth Trust Plc (The) | 111,540 | 111,540 | 982,667.4 | 0.2698 | 0.2265 | 08/31/2026 |
| 11 | ALPS Medical Breakthroughs ETF | 64,778 | 64,778 | 570,694.18 | 0.3052 | 0.1315 | 09/30/2026 |
| 12 | Steward Values Enhanced International Fund | 23,096 | 23,096 | 203,475.76 | 0.0592 | 0.0469 | 08/31/2026 |
| 13 | Federated Hermes Kaufmann Fund II | 21,108 | 0 | 185,961.48 | 0.1745 | 0.0429 | 06/30/2026 |
| 14 | Blackstone Alternative Multi Strategy Fund | 17,665 | 17,665 | 155,628.65 | 0.0099 | 0.0359 | 06/30/2026 |
| 15 | Fidelity Nasdaq Composite Index Fund | 9,531 | 785 | 83,968.11 | 0.0003 | 0.0194 | 08/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Redmile Group LLC | 2,733,926 | 2,577,676 | 24,085,888.06 | 1.7121 | 5.5513 | 06/30/2026 |
| 2 | Nantahala Capital Management LLC | 1,568,188 | 368,188 | 13,815,736.28 | 0.8823 | 3.1843 | 06/30/2026 |
| 3 | abrdn, Inc. | 846,695 | 139,039 | 7,459,382.95 | 0.0694 | 1.7192 | 06/30/2026 |
| 4 | ALPS Advisors, Inc. | 49,984 | 49,984 | 440,359.04 | 0.0018 | 0.1015 | 06/30/2026 |
| 5 | Quadrature Capital Ltd. | 20,461 | 20,461 | 180,261.41 | 0.0015 | 0.0415 | 06/30/2026 |
| 6 | XTX Markets LLC | 10,271 | 10,271 | 90,487.51 | 0.0012 | 0.0209 | 06/30/2026 |
| 7 | Citigroup Global Markets, Inc. (Investment Management) | 9,496 | 9,496 | 83,659.76 | 0 | 0.0193 | 06/30/2026 |
| 8 | Two Sigma Investments LP | 18,072 | 3,831 | 159,214.32 | 0.0001 | 0.0367 | 06/30/2026 |
| 9 | GAMMA Investing LLC | 1,396 | 1,396 | 12,298.76 | 0.0004 | 0.0028 | 09/30/2026 |
| 10 | BNP Paribas Financial Markets SNC | 754 | 754 | 6,642.74 | 0 | 0.0015 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | LMR Partners LLP | 0 | -300,000 | 0 | 0 | 0 | |
| 2 | Seven Grand Managers LLC | 47,600 | -152,400 | 419,356 | 0.0195 | 0.0967 | 06/30/2026 |
| 3 | Millennium Management LLC | 0 | -95,233 | 0 | 0 | 0 | |
| 4 | Alyeska Investment Group LP | 0 | -75,000 | 0 | 0 | 0 | |
| 5 | Laurion Capital Management LP | 0 | -50,000 | 0 | 0 | 0 | |
| 6 | Citadel Advisors LLC | 0 | -35,000 | 0 | 0 | 0 | |
| 7 | Goldman Sachs & Co. LLC (Private Banking) | 11,800 | -23,939 | 103,958 | 0 | 0.024 | 06/30/2026 |
| 8 | D. E. Shaw & Co. LP | 0 | -15,326 | 0 | 0 | 0 | |
| 9 | Jane Street Capital LLC | 0 | -12,794 | 0 | 0 | 0 | |
| 10 | HRT Financial LP | 17,075 | -6,651 | 150,430.75 | 0.0004 | 0.0347 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.