# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Redmile Group LLC 2,733,926 2,733,926 37,837,535.84 2.0856 5.5513 06/30/2026
2 Cormorant Asset Management LP 2,465,348 2,465,348 34,120,416.32 1.6112 5.006 06/30/2026
3 Federated Global Investment Management Corp. 1,618,000 1,618,000 22,393,120 0.185 3.2854 06/30/2026
4 Nantahala Capital Management LLC 1,568,188 1,568,188 21,703,721.92 1.2089 3.1843 06/30/2026
5 Casdin Capital LLC 1,550,000 1,550,000 21,452,000 0.9471 3.1473 06/30/2026
6 Fidelity Management & Research Co. LLC 1,458,677 1,458,677 20,188,089.68 0.001 2.9619 06/30/2026
7 abrdn, Inc. 846,695 846,695 11,718,258.8 0.1016 1.7192 06/30/2026
8 Perceptive Advisors LLC 600,000 600,000 8,304,000 0.1212 1.2183 06/30/2026
9 ALPS Advisors, Inc. 49,984 49,984 691,778.56 0.0026 0.1015 06/30/2026
10 Bellevue Asset Management AG 49,248 49,248 681,592.32 0.0107 0.1 06/30/2026
11 Seven Grand Managers LLC 47,600 47,600 658,784 0.0285 0.0967 06/30/2026
12 Sectoral Asset Management, Inc. 43,500 43,500 602,040 0.3505 0.0883 06/30/2026
13 Burkehill Global Management LP 35,000 35,000 484,400 0.019 0.0711 06/30/2026
14 Quadrature Capital Ltd. 20,461 20,461 283,180.24 0.0023 0.0415 06/30/2026
15 Two Sigma Investments LP 18,072 18,072 250,116.48 0.0002 0.0367 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Federated Hermes Kaufmann Fund 981,184 981,184 13,579,586.56 0.2589 1.9923 06/30/2026
2 Fidelity Growth Company Commingled Pool 671,144 671,144 9,288,632.96 0.007 1.3628 06/30/2026
3 Federated Hermes Kaufmann Small Cap Fund 615,708 615,708 8,521,398.72 0.2789 1.2502 06/30/2026
4 Fidelity Growth Company Fund 507,250 507,250 7,020,340 0.007 1.03 06/30/2026
5 abrdn Healthcare Investors 363,500 363,500 5,030,840 0.3491 0.7381 07/31/2026
6 abrdn World Healthcare Fund 312,731 312,731 4,328,197.04 0.6581 0.635 07/31/2026
7 Fidelity Growth Company K6 Fund 141,983 141,983 1,965,044.72 0.007 0.2883 06/30/2026
8 abrdn Life Sciences Investors 141,787 141,787 1,962,332.08 0.2816 0.2879 03/31/2026
9 Fidelity Series Growth Company Fund 129,200 129,200 1,788,128 0.0075 0.2623 06/30/2026
10 Biotech Growth Trust Plc (The) 111,540 111,540 1,543,713.6 0.3262 0.2265 07/31/2026
11 ALPS Medical Breakthroughs ETF 53,782 53,782 744,342.88 0.3376 0.1092 07/31/2026
12 Protea Fund - Sectoral Healthcare Opportunities Fund 26,935 26,935 372,780.4 0.444 0.0547 07/31/2026
13 Federated Hermes Kaufmann Fund II 21,108 21,108 292,134.72 0.2604 0.0429 06/30/2026
14 Protea Fund - Sectoral Biotech Opportunities Fund 16,565 16,565 229,259.6 0.7153 0.0336 07/31/2026
15 Fidelity Select Pharmaceuticals Portfolio 9,100 9,100 125,944 0.0077 0.0185 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Redmile Group LLC 2,733,926 2,733,926 37,837,535.84 2.0856 5.5513 06/30/2026
2 Cormorant Asset Management LP 2,465,348 2,465,348 34,120,416.32 1.6112 5.006 06/30/2026
3 Federated Global Investment Management Corp. 1,618,000 1,618,000 22,393,120 0.185 3.2854 06/30/2026
4 Nantahala Capital Management LLC 1,568,188 1,568,188 21,703,721.92 1.2089 3.1843 06/30/2026
5 Casdin Capital LLC 1,550,000 1,550,000 21,452,000 0.9471 3.1473 06/30/2026
6 Fidelity Management & Research Co. LLC 1,458,677 1,458,677 20,188,089.68 0.001 2.9619 06/30/2026
7 abrdn, Inc. 846,695 846,695 11,718,258.8 0.1016 1.7192 06/30/2026
8 Perceptive Advisors LLC 600,000 600,000 8,304,000 0.1212 1.2183 06/30/2026
9 ALPS Advisors, Inc. 49,984 49,984 691,778.56 0.0026 0.1015 06/30/2026
10 Bellevue Asset Management AG 49,248 49,248 681,592.32 0.0107 0.1 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
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Data provided by FactSet Research Systems Inc.