| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 0 | 2,563,793,842.56 | 20.6594 | 16.4829 | 06/30/2026 |
| 2 | T. Rowe Price Investment Management, Inc. | 6,754,846 | 5,087,221 | 1,684,388,398.56 | 1.0727 | 10.8291 | 06/30/2026 |
| 3 | Avoro Capital Advisor LLC | 5,111,111 | 0 | 1,274,506,638.96 | 11.2432 | 8.1939 | 06/30/2026 |
| 4 | Westfield Capital Management Co. LP | 4,798,267 | -387,429 | 1,196,495,859.12 | 3.9655 | 7.6924 | 06/30/2026 |
| 5 | Janus Henderson Investors US LLC | 3,594,673 | -326,394 | 896,367,659.28 | 0.3878 | 5.7628 | 06/30/2026 |
| 6 | Fidelity Management & Research Co. LLC | 3,240,762 | -561,024 | 808,116,412.32 | 0.0384 | 5.1955 | 06/30/2026 |
| 7 | Artisan Partners LP | 2,634,024 | -591,861 | 656,820,224.64 | 0.5013 | 4.2228 | 06/30/2026 |
| 8 | Capital Research & Management Co. (International Investors) | 1,988,614 | -1,075,329 | 495,880,787.04 | 0.0856 | 3.1881 | 06/30/2026 |
| 9 | BlackRock Fund Advisors | 1,846,188 | 1,501,106 | 460,365,439.68 | 0.0083 | 2.9597 | 06/30/2026 |
| 10 | Massachusetts Financial Services Co. | 1,815,615 | -10,719 | 452,741,756.4 | 0.1408 | 2.9107 | 06/30/2026 |
| 11 | Franklin Advisers, Inc. | 1,654,989 | 80,565 | 412,688,057.04 | 0.1754 | 2.6532 | 06/30/2026 |
| 12 | Wellington Management Co. LLP | 1,504,786 | -212,505 | 375,233,436.96 | 0.0594 | 2.4124 | 06/30/2026 |
| 13 | American Century Investment Management, Inc. | 1,400,575 | -42,566 | 349,247,382 | 0.1109 | 2.2453 | 06/30/2026 |
| 14 | Perceptive Advisors LLC | 1,163,721 | 82,300 | 290,185,468.56 | 4.2352 | 1.8656 | 06/30/2026 |
| 15 | T. Rowe Price Associates, Inc. (IM) | 1,097,778 | -472,482 | 273,741,922.08 | 0.0296 | 1.7599 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Capital Appreciation Fund | 3,364,767 | 3,364,767 | 839,038,299.12 | 1.6369 | 5.3943 | 06/30/2026 |
| 2 | MFS Mid Cap Growth Fund | 1,273,836 | -5,902 | 317,643,744.96 | 2.3286 | 2.0422 | 07/31/2026 |
| 3 | American Funds Growth Fund of America | 1,209,675 | 0 | 301,644,558 | 0.0861 | 1.9393 | 06/30/2026 |
| 4 | Vanguard Health Care Fund | 1,049,942 | -53,527 | 261,813,537.12 | 0.6299 | 1.6832 | 04/30/2026 |
| 5 | Franklin DynaTech Fund | 1,000,000 | 0 | 249,360,000 | 0.8365 | 1.6032 | 06/30/2026 |
| 6 | JNL/T Rowe Price Capital Appreciation Fund | 795,727 | 795,727 | 198,422,484.72 | 1.968 | 1.2757 | 06/30/2026 |
| 7 | American Century Ultra Fund | 664,000 | 0 | 165,575,040 | 0.6066 | 1.0645 | 06/30/2026 |
| 8 | T Rowe Price Mid Cap Growth Fund | 639,106 | -144,994 | 159,367,472.16 | 0.6851 | 1.0246 | 06/30/2026 |
| 9 | Polar Capital Funds Plc - Biotechnology Fund | 583,990 | 183,990 | 145,623,746.4 | 3.6543 | 0.9362 | 06/30/2026 |
| 10 | American Funds Small Cap World Fund | 570,650 | -8,515 | 142,297,284 | 0.1582 | 0.9148 | 06/30/2026 |
| 11 | Fidelity Select Port. - Health Care Portfolio | 540,000 | -176,000 | 134,654,400 | 1.948 | 0.8657 | 06/30/2026 |
| 12 | Artisan Mid Cap Fund | 539,946 | -165,224 | 134,640,934.56 | 4.2998 | 0.8656 | 06/30/2026 |
| 13 | Harbor Small Cap Growth Fund | 499,143 | -23,070 | 124,466,298.48 | 4.8626 | 0.8002 | 04/30/2026 |
| 14 | Fidelity Select Port. - Biotechnology Portfolio | 480,401 | -89,300 | 119,792,793.36 | 1.8949 | 0.7702 | 06/30/2026 |
| 15 | T. Rowe Price Capital Appreciation Equity ETF | 469,599 | 469,599 | 117,099,206.64 | 1.4118 | 0.7528 | 07/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 6,754,846 | 5,087,221 | 1,684,388,398.56 | 1.0727 | 10.8291 | 06/30/2026 |
| 2 | BlackRock Fund Advisors | 1,846,188 | 1,501,106 | 460,365,439.68 | 0.0083 | 2.9597 | 06/30/2026 |
| 3 | Capital Research & Management Co. (World Investors) | 906,081 | 906,081 | 225,940,358.16 | 0.0197 | 1.4526 | 06/30/2026 |
| 4 | SSgA Funds Management, Inc. | 513,969 | 446,020 | 128,163,309.84 | 0.0036 | 0.824 | 06/30/2026 |
| 5 | Geode Capital Management LLC | 403,151 | 334,296 | 100,529,733.36 | 0.0043 | 0.6463 | 06/30/2026 |
| 6 | Polar Capital LLP | 616,908 | 246,435 | 153,832,178.88 | 0.2881 | 0.989 | 06/30/2026 |
| 7 | Vestal Point Capital LP | 375,000 | 200,000 | 93,510,000 | 2.1195 | 0.6012 | 06/30/2026 |
| 8 | Jane Street Capital LLC | 187,141 | 165,916 | 46,665,479.76 | 0.0273 | 0.3 | 06/30/2026 |
| 9 | Pictet Asset Management SA | 234,039 | 160,621 | 58,359,965.04 | 0.0361 | 0.3752 | 06/30/2026 |
| 10 | SilverArc Capital Management LLC | 206,234 | 157,006 | 51,426,510.24 | 5.514 | 0.3306 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Capital Research & Management Co. (International Investors) | 1,988,614 | -1,075,329 | 495,880,787.04 | 0.0856 | 3.1881 | 06/30/2026 |
| 2 | Artisan Partners LP | 2,634,024 | -591,861 | 656,820,224.64 | 0.5013 | 4.2228 | 06/30/2026 |
| 3 | Fidelity Management & Research Co. LLC | 3,240,762 | -561,024 | 808,116,412.32 | 0.0384 | 5.1955 | 06/30/2026 |
| 4 | Nomura Investment Management Business Trust | 0 | -496,837 | 0 | 0 | 0 | |
| 5 | T. Rowe Price Associates, Inc. (IM) | 1,097,778 | -472,482 | 273,741,922.08 | 0.0296 | 1.7599 | 06/30/2026 |
| 6 | Susquehanna Financial Group LLLP | 1,215 | -469,736 | 302,972.4 | 0.0003 | 0.0019 | 06/30/2026 |
| 7 | Westfield Capital Management Co. LP | 4,798,267 | -387,429 | 1,196,495,859.12 | 3.9655 | 7.6924 | 06/30/2026 |
| 8 | Citadel Advisors LLC | 125,411 | -371,470 | 31,272,486.96 | 0.0228 | 0.2011 | 06/30/2026 |
| 9 | Janus Henderson Investors US LLC | 3,594,673 | -326,394 | 896,367,659.28 | 0.3878 | 5.7628 | 06/30/2026 |
| 10 | DWS Investments (UK) Ltd. | 0 | -254,118 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.