| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 0 | 2,333,899,592 | 23.3189 | 16.4829 | 06/30/2026 |
| 2 | T. Rowe Price Investment Management, Inc. | 6,754,846 | 592,804 | 1,533,350,042 | 0.9972 | 10.8291 | 06/30/2026 |
| 3 | Avoro Capital Advisor LLC | 5,111,111 | 48,611 | 1,160,222,197 | 12.4052 | 8.1939 | 06/30/2026 |
| 4 | Westfield Capital Management Co. LP | 4,798,267 | -15,173 | 1,089,206,609 | 3.7212 | 7.6924 | 06/30/2026 |
| 5 | Janus Henderson Investors US LLC | 3,594,673 | -124,779 | 815,990,771 | 0.3617 | 5.7628 | 06/30/2026 |
| 6 | Fidelity Management & Research Co. LLC | 3,240,762 | -317,324 | 735,652,974 | 0.0348 | 5.1955 | 06/30/2026 |
| 7 | Artisan Partners LP | 2,634,024 | -596,164 | 597,923,448 | 0.4887 | 4.2228 | 06/30/2026 |
| 8 | Capital Research & Management Co. (International Investors) | 1,988,614 | 29,771 | 451,415,378 | 0.0785 | 3.1881 | 06/30/2026 |
| 9 | BlackRock Fund Advisors | 1,846,188 | 1,493,825 | 419,084,676 | 0.0077 | 2.9597 | 06/30/2026 |
| 10 | Massachusetts Financial Services Co. | 1,815,615 | 14,357 | 412,144,605 | 0.1314 | 2.9107 | 06/30/2026 |
| 11 | Franklin Advisers, Inc. | 1,654,989 | -103,334 | 375,682,503 | 0.1611 | 2.6532 | 06/30/2026 |
| 12 | Wellington Management Co. LLP | 1,504,786 | -206,037 | 341,586,422 | 0.0549 | 2.4124 | 06/30/2026 |
| 13 | American Century Investment Management, Inc. | 1,400,575 | 3,456 | 317,930,525 | 0.1019 | 2.2453 | 06/30/2026 |
| 14 | Perceptive Advisors LLC | 1,163,721 | -367,700 | 264,164,667 | 4.8568 | 1.8656 | 06/30/2026 |
| 15 | T. Rowe Price Associates, Inc. (IM) | 1,097,778 | -432,567 | 249,195,606 | 0.027 | 1.7599 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Capital Appreciation Fund | 3,364,767 | 624,000 | 763,802,109 | 1.46 | 5.3943 | 06/30/2026 |
| 2 | MFS Mid Cap Growth Fund | 1,273,836 | 0 | 289,160,772 | 2.1799 | 2.0422 | 07/31/2026 |
| 3 | American Funds Growth Fund of America | 1,209,675 | 0 | 274,596,225 | 0.0779 | 1.9393 | 06/30/2026 |
| 4 | Vanguard Health Care Fund | 1,099,854 | -3,615 | 249,666,858 | 0.6388 | 1.7632 | 07/31/2026 |
| 5 | Franklin DynaTech Fund | 1,000,000 | -100,000 | 227,000,000 | 0.7531 | 1.6032 | 08/31/2026 |
| 6 | JNL/T Rowe Price Capital Appreciation Fund | 795,727 | 192,408 | 180,630,029 | 1.7519 | 1.2757 | 06/30/2026 |
| 7 | T. Rowe Price Capital Appreciation Equity ETF | 702,705 | 369,475 | 159,514,035 | 1.8035 | 1.1265 | 09/30/2026 |
| 8 | American Century Ultra Fund | 664,000 | 0 | 150,728,000 | 0.5385 | 1.0645 | 06/30/2026 |
| 9 | T Rowe Price Mid Cap Growth Fund | 639,106 | -144,294 | 145,077,062 | 0.6299 | 1.0246 | 06/30/2026 |
| 10 | Polar Capital Funds Plc - Biotechnology Fund | 613,671 | -2,261 | 139,303,317 | 3.8894 | 0.9838 | 08/28/2026 |
| 11 | American Funds Small Cap World Fund | 570,650 | -8,515 | 129,537,550 | 0.1503 | 0.9148 | 06/30/2026 |
| 12 | Artisan Mid Cap Fund | 539,946 | -138,397 | 122,567,742 | 4.0461 | 0.8656 | 06/30/2026 |
| 13 | Fidelity Select Port. - Health Care Portfolio | 500,000 | -200,000 | 113,500,000 | 1.6926 | 0.8016 | 08/31/2026 |
| 14 | iShares Biotechnology ETF | 484,703 | 144,755 | 110,027,581 | 1.0121 | 0.7771 | 09/30/2026 |
| 15 | Fidelity Select Port. - Biotechnology Portfolio | 480,401 | -22,000 | 109,051,027 | 1.8642 | 0.7702 | 08/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | BlackRock Fund Advisors | 1,846,188 | 1,493,825 | 419,084,676 | 0.0077 | 2.9597 | 06/30/2026 |
| 2 | T. Rowe Price Investment Management, Inc. | 6,754,846 | 592,804 | 1,533,350,042 | 0.9972 | 10.8291 | 06/30/2026 |
| 3 | SSgA Funds Management, Inc. | 513,969 | 426,635 | 116,670,963 | 0.0032 | 0.824 | 06/30/2026 |
| 4 | Geode Capital Management LLC | 403,151 | 330,210 | 91,515,277 | 0.0039 | 0.6463 | 06/30/2026 |
| 5 | UBS Securities LLC | 338,820 | 201,157 | 76,912,140 | 0.0289 | 0.5432 | 06/30/2026 |
| 6 | Jane Street Capital LLC | 187,141 | 187,141 | 42,481,007 | 0.0248 | 0.3 | 06/30/2026 |
| 7 | Neuberger Berman Investment Advisers LLC | 142,705 | 142,705 | 32,394,035 | 0.0209 | 0.2288 | 06/30/2026 |
| 8 | USS Investment Management Ltd. | 141,010 | 141,010 | 32,009,270 | 0.1207 | 0.2261 | 06/30/2026 |
| 9 | Empowered Funds LLC | 187,271 | 136,136 | 42,510,517 | 0.1907 | 0.3002 | 06/30/2026 |
| 10 | Walleye Capital LLC | 126,205 | 126,168 | 28,648,535 | 0.102 | 0.2023 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Artisan Partners LP | 2,634,024 | -596,164 | 597,923,448 | 0.4887 | 4.2228 | 06/30/2026 |
| 2 | Nomura Investment Management Business Trust | 0 | -556,427 | 0 | 0 | 0 | |
| 3 | T. Rowe Price Associates, Inc. (IM) | 1,097,778 | -432,567 | 249,195,606 | 0.027 | 1.7599 | 06/30/2026 |
| 4 | Perceptive Advisors LLC | 1,163,721 | -367,700 | 264,164,667 | 4.8568 | 1.8656 | 06/30/2026 |
| 5 | Fidelity Management & Research Co. LLC | 3,240,762 | -317,324 | 735,652,974 | 0.0348 | 5.1955 | 06/30/2026 |
| 6 | Candriam Belgium SA | 0 | -230,278 | 0 | 0 | 0 | |
| 7 | Wellington Management Co. LLP | 1,504,786 | -206,037 | 341,586,422 | 0.0549 | 2.4124 | 06/30/2026 |
| 8 | abrdn Investment Management Ltd. | 0 | -173,642 | 0 | 0 | 0 | |
| 9 | Columbia Management Investment Advisers LLC | 320,463 | -155,953 | 72,745,101 | 0.0152 | 0.5138 | 06/30/2026 |
| 10 | Spyglass Capital Management LLC | 215,398 | -152,574 | 48,895,346 | 2.7126 | 0.3453 | 06/30/2026 |
Data provided by FactSet Research Systems Inc.