| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RA Capital Management LP | 10,281,496 | 0 | 2,241,983,017.76 | 21.8638 | 16.4829 | 03/31/2026 |
| 2 | T. Rowe Price Investment Management, Inc. | 6,506,219 | 3,839,601 | 1,418,746,115.14 | 0.8776 | 10.4305 | 04/30/2026 |
| 3 | Avoro Capital Advisor LLC | 5,062,500 | -47,500 | 1,103,928,750 | 11.4275 | 8.116 | 03/31/2026 |
| 4 | Westfield Capital Management Co. LP | 4,813,440 | -446,469 | 1,049,618,726.4 | 3.7715 | 7.7167 | 03/31/2026 |
| 5 | Fidelity Management & Research Co. LLC | 3,558,086 | -561,551 | 775,876,233.16 | 0.0388 | 5.7042 | 03/31/2026 |
| 6 | Artisan Partners LP | 3,230,188 | -490,692 | 704,374,795.28 | 0.5294 | 5.1785 | 03/31/2026 |
| 7 | Capital Research & Management Co. (International Investors) | 1,958,843 | -1,101,773 | 427,145,304.58 | 0.0799 | 3.1403 | 03/31/2026 |
| 8 | Massachusetts Financial Services Co. | 1,801,258 | -970 | 392,782,319.48 | 0.1241 | 2.8877 | 03/31/2026 |
| 9 | Franklin Advisers, Inc. | 1,758,323 | 584,934 | 383,419,913.38 | 0.1679 | 2.8189 | 03/31/2026 |
| 10 | Wellington Management Co. LLP | 1,710,823 | -41,278 | 373,062,063.38 | 0.0587 | 2.7427 | 03/31/2026 |
| 11 | Perceptive Advisors LLC | 1,531,421 | 442,920 | 333,941,663.26 | 6.3551 | 2.4551 | 03/31/2026 |
| 12 | T. Rowe Price Associates, Inc. (IM) | 1,530,345 | -195,883 | 333,707,030.7 | 0.0379 | 2.4534 | 03/31/2026 |
| 13 | American Century Investment Management, Inc. | 1,397,119 | 852,513 | 304,655,769.14 | 0.1032 | 2.2398 | 03/31/2026 |
| 14 | Capital Research & Management Co. (World Investors) | 900,517 | 900,517 | 196,366,737.02 | 0.0176 | 1.4437 | 03/31/2026 |
| 15 | Principal Global Investors LLC | 896,397 | 102,720 | 195,468,329.82 | 0.0847 | 1.4371 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Capital Appreciation Fund | 2,740,767 | 2,740,767 | 597,651,652.02 | 1.2284 | 4.3939 | 03/31/2026 |
| 2 | MFS Mid Cap Growth Fund | 1,273,836 | -5,902 | 277,772,678.16 | 1.9913 | 2.0422 | 04/30/2026 |
| 3 | American Funds Growth Fund of America | 1,209,675 | 147,541 | 263,781,730.5 | 0.0779 | 1.9393 | 03/31/2026 |
| 4 | Vanguard Health Care Fund | 1,103,469 | 0 | 240,622,450.14 | 0.6192 | 1.769 | 01/31/2026 |
| 5 | Franklin DynaTech Fund | 1,100,000 | 275,000 | 239,866,000 | 0.8303 | 1.7635 | 04/30/2026 |
| 6 | T Rowe Price Mid Cap Growth Fund | 783,400 | -232,000 | 170,828,204 | 0.7109 | 1.2559 | 03/31/2026 |
| 7 | T Rowe Price Health Sciences Fund | 699,373 | -137,438 | 152,505,276.38 | 1.3448 | 1.1212 | 03/31/2026 |
| 8 | Artisan Mid Cap Fund | 678,343 | -139,709 | 147,919,474.58 | 4.4875 | 1.0875 | 03/31/2026 |
| 9 | Fidelity Select Port. - Health Care Portfolio | 670,000 | -70,000 | 146,100,200 | 2.4759 | 1.0741 | 04/30/2026 |
| 10 | American Century Ultra Fund | 664,000 | 664,000 | 144,791,840 | 0.5361 | 1.0645 | 03/31/2026 |
| 11 | Polar Capital Funds Plc - Biotechnology Fund | 615,932 | 265,932 | 134,310,131.92 | 4.234 | 0.9874 | 04/30/2026 |
| 12 | JNL/T Rowe Price Capital Appreciation Fund | 603,319 | 603,319 | 131,559,741.14 | 1.3691 | 0.9672 | 03/31/2026 |
| 13 | American Funds Small Cap World Fund | 579,165 | 0 | 126,292,719.9 | 0.1419 | 0.9285 | 03/31/2026 |
| 14 | Bridge Builder Small/Mid Cap Growth Fund | 531,734 | -69,481 | 115,949,916.04 | 1.0851 | 0.8525 | 05/29/2026 |
| 15 | Harbor Small Cap Growth Fund | 522,213 | -42,540 | 113,873,766.78 | 4.4549 | 0.8372 | 01/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | T. Rowe Price Investment Management, Inc. | 6,506,219 | 3,839,601 | 1,418,746,115.14 | 0.8776 | 10.4305 | 04/30/2026 |
| 2 | Capital Research & Management Co. (World Investors) | 900,517 | 900,517 | 196,366,737.02 | 0.0176 | 1.4437 | 03/31/2026 |
| 3 | American Century Investment Management, Inc. | 1,397,119 | 852,513 | 304,655,769.14 | 0.1032 | 2.2398 | 03/31/2026 |
| 4 | Franklin Advisers, Inc. | 1,758,323 | 584,934 | 383,419,913.38 | 0.1679 | 2.8189 | 03/31/2026 |
| 5 | Perceptive Advisors LLC | 1,531,421 | 442,920 | 333,941,663.26 | 6.3551 | 2.4551 | 03/31/2026 |
| 6 | JPMorgan Securities LLC (Investment Management) | 426,482 | 296,913 | 92,998,664.92 | 0.0436 | 0.6837 | 03/31/2026 |
| 7 | Nomura Investment Management Business Trust | 556,427 | 246,888 | 121,334,471.62 | 0.1432 | 0.892 | 03/31/2026 |
| 8 | BlackRock Investment Management (UK) Ltd. | 221,808 | 211,144 | 48,367,452.48 | 0.0055 | 0.3556 | 03/31/2026 |
| 9 | Pictet Asset Management SA | 251,833 | 174,775 | 54,914,703.98 | 0.034 | 0.4037 | 03/31/2026 |
| 10 | abrdn Investment Management Ltd. | 173,642 | 173,642 | 37,864,374.52 | 0.0382 | 0.2784 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 0 | -4,234,533 | 0 | 0 | 0 | |
| 2 | Capital Research & Management Co. (International Investors) | 1,958,843 | -1,101,773 | 427,145,304.58 | 0.0799 | 3.1403 | 03/31/2026 |
| 3 | Invesco Advisers, Inc. | 303,575 | -581,593 | 66,197,564.5 | 0.0261 | 0.4867 | 03/31/2026 |
| 4 | Fidelity Management & Research Co. LLC | 3,558,086 | -561,551 | 775,876,233.16 | 0.0388 | 5.7042 | 03/31/2026 |
| 5 | Artisan Partners LP | 3,230,188 | -490,692 | 704,374,795.28 | 0.5294 | 5.1785 | 03/31/2026 |
| 6 | Westfield Capital Management Co. LP | 4,813,440 | -446,469 | 1,049,618,726.4 | 3.7715 | 7.7167 | 03/31/2026 |
| 7 | Qube Research & Technologies Ltd. | 52,753 | -237,419 | 11,503,319.18 | 0.0147 | 0.0846 | 03/31/2026 |
| 8 | Vestal Point Capital LP | 375,000 | -225,000 | 81,772,500 | 2.2269 | 0.6012 | 03/31/2026 |
| 9 | Polar Capital LLP | 651,712 | -206,199 | 142,112,318.72 | 0.2794 | 1.0448 | 03/31/2026 |
| 10 | T. Rowe Price Associates, Inc. (IM) | 1,530,345 | -195,883 | 333,707,030.7 | 0.0379 | 2.4534 | 03/31/2026 |
Data provided by FactSet Research Systems Inc.