| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Darwin Global Management Ltd. | 3,077,219 | 19,807 | 467,337,249.53 | 8.7414 | 7.6411 | 06/30/2026 |
| 2 | Paradigm BioCapital Advisors LP | 1,232,877 | 118,093 | 187,237,029.99 | 4.412 | 3.0614 | 06/30/2026 |
| 3 | RTW Investments LP | 715,332 | 0 | 108,637,470.84 | 1.0505 | 1.7762 | 06/30/2026 |
| 4 | Millennium Management LLC | 494,564 | -75,524 | 75,109,434.68 | 0.0519 | 1.2281 | 06/30/2026 |
| 5 | Maverick Capital Ltd. | 396,311 | 396,311 | 60,187,751.57 | 0.5347 | 0.9841 | 06/30/2026 |
| 6 | Eventide Asset Management LLC | 390,829 | 33,179 | 59,355,200.23 | 0.8698 | 0.9705 | 06/30/2026 |
| 7 | Holocene Advisors, LP | 251,035 | -243,460 | 38,124,685.45 | 0.0867 | 0.6233 | 06/30/2026 |
| 8 | Logos Global Management LP | 250,000 | 250,000 | 37,967,500 | 2.0812 | 0.6208 | 06/30/2026 |
| 9 | Morgan Stanley & Co. LLC | 231,121 | 75,578 | 35,100,346.27 | 0.0102 | 0.5739 | 06/30/2026 |
| 10 | UBS Securities LLC | 224,876 | -491,777 | 34,151,918.12 | 0.0128 | 0.5584 | 06/30/2026 |
| 11 | Citadel Advisors LLC | 176,210 | 174,202 | 26,761,012.7 | 0.0202 | 0.4375 | 06/30/2026 |
| 12 | Goldman Sachs & Co. LLC (Private Banking) | 166,188 | 60,679 | 25,238,971.56 | 0.0064 | 0.4127 | 06/30/2026 |
| 13 | Affinity Asset Advisors LLC | 165,000 | 100,000 | 25,058,550 | 1.6928 | 0.4097 | 06/30/2026 |
| 14 | T. Rowe Price Associates, Inc. (IM) | 105,859 | -175,946 | 16,076,806.33 | 0.0017 | 0.2629 | 06/30/2026 |
| 15 | Bank of America, NA (Private Banking) | 99,492 | 97,246 | 15,109,850.04 | 0.0039 | 0.247 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FCP Medical - BioHealth | 97,479 | -32,671 | 14,804,135.73 | 1.5537 | 0.2421 | 07/31/2026 |
| 2 | Eventide Healthcare & Life Sciences Fund | 62,205 | 33,179 | 9,447,073.35 | 0.6215 | 0.1545 | 06/30/2026 |
| 3 | UPAMC Global AIoT Fund | 48,010 | 1,426 | 7,291,278.7 | 3.587 | 0.1192 | 06/30/2026 |
| 4 | State Street SPDR Portfolio Emerging Markets ETF | 30,060 | 17,604 | 4,565,212.2 | 0.026 | 0.0746 | 09/30/2026 |
| 5 | APO Medical Opportunities | 23,156 | 0 | 3,516,701.72 | 0.5047 | 0.0575 | 03/31/2026 |
| 6 | UPAMC China Fund | 19,987 | 770 | 3,035,425.69 | 4.2393 | 0.0496 | 06/30/2026 |
| 7 | Biotech Growth Trust Plc (The) | 13,300 | 13,300 | 2,019,871 | 0.5547 | 0.033 | 08/31/2026 |
| 8 | RIM Global - Bioscience | 12,806 | 0 | 1,944,847.22 | 1.9151 | 0.0318 | 06/30/2026 |
| 9 | Fidelity Nasdaq Composite Index Fund | 6,727 | 0 | 1,021,629.49 | 0.0035 | 0.0167 | 08/31/2026 |
| 10 | Fidelity ZERO International Index Fund | 5,934 | 5,934 | 901,196.58 | 0.0072 | 0.0147 | 08/31/2026 |
| 11 | FSITC AI Global Precision Medicine Fund | 4,697 | -604 | 713,333.39 | 1.0853 | 0.0117 | 06/30/2026 |
| 12 | ActivePassive International Equity ETF | 4,286 | 2,969 | 650,914.82 | 0.057 | 0.0106 | 09/30/2026 |
| 13 | Fidelity Nasdaq Composite Index ETF | 3,745 | 45 | 568,753.15 | 0.0051 | 0.0093 | 09/30/2026 |
| 14 | State Street SPDR S&P China ETF | 3,192 | 0 | 484,769.04 | 0.1078 | 0.0079 | 09/30/2026 |
| 15 | Fidelity Select Port. - Biotechnology Portfolio | 3,100 | 3,100 | 470,797 | 0.0083 | 0.0077 | 08/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Maverick Capital Ltd. | 396,311 | 396,311 | 60,187,751.57 | 0.5347 | 0.9841 | 06/30/2026 |
| 2 | Logos Global Management LP | 250,000 | 250,000 | 37,967,500 | 2.0812 | 0.6208 | 06/30/2026 |
| 3 | Citadel Advisors LLC | 176,210 | 174,202 | 26,761,012.7 | 0.0202 | 0.4375 | 06/30/2026 |
| 4 | Paradigm BioCapital Advisors LP | 1,232,877 | 118,093 | 187,237,029.99 | 4.412 | 3.0614 | 06/30/2026 |
| 5 | Affinity Asset Advisors LLC | 165,000 | 100,000 | 25,058,550 | 1.6928 | 0.4097 | 06/30/2026 |
| 6 | Bank of America, NA (Private Banking) | 99,492 | 97,246 | 15,109,850.04 | 0.0039 | 0.247 | 06/30/2026 |
| 7 | Morgan Stanley & Co. LLC | 231,121 | 75,578 | 35,100,346.27 | 0.0102 | 0.5739 | 06/30/2026 |
| 8 | Goldman Sachs & Co. LLC (Private Banking) | 166,188 | 60,679 | 25,238,971.56 | 0.0064 | 0.4127 | 06/30/2026 |
| 9 | Jane Street Capital LLC | 65,801 | 53,579 | 9,993,197.87 | 0.0058 | 0.1634 | 06/30/2026 |
| 10 | Point72 Asset Management LP | 51,186 | 51,186 | 7,773,617.82 | 0.0123 | 0.1271 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | UBS Securities LLC | 224,876 | -491,777 | 34,151,918.12 | 0.0128 | 0.5584 | 06/30/2026 |
| 2 | Holocene Advisors, LP | 251,035 | -243,460 | 38,124,685.45 | 0.0867 | 0.6233 | 06/30/2026 |
| 3 | T. Rowe Price Associates, Inc. (IM) | 105,859 | -175,946 | 16,076,806.33 | 0.0017 | 0.2629 | 06/30/2026 |
| 4 | Perceptive Advisors LLC | 0 | -151,979 | 0 | 0 | 0 | |
| 5 | HBM Partners AG (Investment Management) | 0 | -90,000 | 0 | 0 | 0 | |
| 6 | Fubon Asset Management Co., Ltd. | 0 | -79,954 | 0 | 0 | 0 | |
| 7 | Millennium Management LLC | 494,564 | -75,524 | 75,109,434.68 | 0.0519 | 1.2281 | 06/30/2026 |
| 8 | Fred Alger Management LLC | 2,119 | -60,455 | 321,812.53 | 0.0011 | 0.0053 | 06/30/2026 |
| 9 | UBS Europe SE | 113 | -51,593 | 17,161.31 | 0.0002 | 0.0003 | 06/30/2026 |
| 10 | Morgan Stanley Investment Management, Inc. | 0 | -42,036 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.