# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Management & Research Co. LLC 7,077,981 1,862,909 678,353,699.04 0.0321 2.9443 06/30/2026
2 PRIMECAP Management Co. 3,772,031 -21,680 361,511,451.04 0.2186 1.5691 06/30/2026
3 Dodge & Cox 3,677,591 800 352,460,321.44 0.1342 1.5298 06/30/2026
4 Flossbach von Storch SE 2,226,138 -1,454,177 213,353,065.92 0.5145 0.926 06/30/2026
5 T. Rowe Price Investment Management, Inc. 2,065,456 -3,790,617 197,953,303.04 0.1287 0.8592 06/30/2026
6 Temasek Holdings Pte Ltd. (Investment Management) 1,506,027 0 144,337,627.68 0.2639 0.6265 06/30/2026
7 BNP Paribas Financial Markets SNC 1,319,517 -332,272 126,462,509.28 0.065 0.5489 06/30/2026
8 Logos Global Management LP 1,015,000 1,015,000 97,277,600 5.0855 0.4222 06/30/2026
9 Fidelity Management & Research (Hong Kong) Ltd. 805,051 258,551 77,156,087.84 0.428 0.3349 08/31/2026
10 BlackRock Fund Advisors 803,924 91,084 77,048,076.16 0.0014 0.3344 06/30/2026
11 First Trust Advisors LP 791,469 -48,522 75,854,388.96 0.0402 0.3292 06/30/2026
12 Davern Capital Partners LP 754,550 449,495 72,316,072 13.6141 0.3139 06/30/2026
13 ACATIS Investment Kapitalverwaltungsgesellschaft mbH 668,282 28 64,048,146.88 1.0954 0.278 07/31/2026
14 Massachusetts Financial Services Co. 651,883 7,145 62,476,466.72 0.0199 0.2712 06/30/2026
15 BlackRock Investment Management (UK) Ltd. 626,135 24,736 60,008,778.4 0.0066 0.2605 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Contrafund 3,847,315 1,807,462 368,726,669.6 0.2017 1.6004 08/31/2026
2 Dodge & Cox International Stock Fund 2,517,713 0 241,297,613.92 0.3719 1.0473 06/30/2026
3 Flossbach von Storch - Multiple Opportunities 2,426,536 0 232,559,210.24 1.0028 1.0094 03/31/2026
4 Vanguard Capital Opportunity Fund 2,189,120 0 209,805,260.8 0.6705 0.9106 06/30/2026
5 Fidelity Contrafund Commingled Pool 1,432,130 701,967 137,255,339.2 0.2064 0.5957 08/31/2026
6 T Rowe Price Mid Cap Growth Fund 1,018,613 -687 97,623,869.92 0.4239 0.4237 06/30/2026
7 First Trust NYSE Arca Biotechnology Index Fund 989,580 181,869 94,841,347.2 3.2966 0.4117 09/30/2026
8 Flossbach von Storch - Multiple Opportunities II 975,000 0 93,444,000 0.9431 0.4056 03/31/2026
9 PRIMECAP Odyssey Aggressive Growth Fund 899,516 -19,630 86,209,613.44 1.0899 0.3742 06/30/2026
10 Fidelity Contrafund K6 820,937 376,333 78,678,602.08 0.2062 0.3415 08/31/2026
11 Fidelity Emerging Markets Fund 766,000 219,500 73,413,440 0.6554 0.3186 08/31/2026
12 iShares Biotechnology ETF 752,431 152,925 72,112,987.04 0.6633 0.313 09/30/2026
13 Dodge & Cox Global Stock Fund 525,778 0 50,390,563.52 0.3873 0.2187 06/30/2026
14 MFS Mid Cap Value Fund 497,120 4,129 47,643,980.8 0.281 0.2068 07/31/2026
15 ProfitlichSchmidlin Fonds UI 368,633 15,250 35,329,786.72 6.9645 0.1533 05/29/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Management & Research Co. LLC 7,077,981 1,862,909 678,353,699.04 0.0321 2.9443 06/30/2026
2 Logos Global Management LP 1,015,000 1,015,000 97,277,600 5.0855 0.4222 06/30/2026
3 Goldman Sachs & Co. LLC (Private Banking) 568,107 492,992 54,447,374.88 0.0139 0.2363 06/30/2026
4 Davern Capital Partners LP 754,550 449,495 72,316,072 13.6141 0.3139 06/30/2026
5 Assenagon Asset Management SA (Germany) 423,263 423,263 40,565,525.92 0.0503 0.1761 06/30/2026
6 Balyasny Asset Management LP 463,163 369,708 44,389,541.92 0.0848 0.1927 06/30/2026
7 Point72 Asset Management LP 327,184 327,184 31,357,314.56 0.0495 0.1361 06/30/2026
8 Fidelity Management & Research (Hong Kong) Ltd. 805,051 258,551 77,156,087.84 0.428 0.3349 08/31/2026
9 D. E. Shaw & Co. LP 417,421 217,653 40,005,628.64 0.0248 0.1736 06/30/2026
10 Franklin Advisers, Inc. 205,822 199,833 19,725,980.48 0.0085 0.0856 06/30/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 T. Rowe Price Investment Management, Inc. 2,065,456 -3,790,617 197,953,303.04 0.1287 0.8592 06/30/2026
2 Flossbach von Storch SE 2,226,138 -1,454,177 213,353,065.92 0.5145 0.926 06/30/2026
3 Citadel Advisors LLC 219,872 -563,301 21,072,532.48 0.0159 0.0915 06/30/2026
4 BNP Paribas Financial Markets SNC 1,319,517 -332,272 126,462,509.28 0.065 0.5489 06/30/2026
5 Bank of America, NA (Private Banking) 462,323 -322,564 44,309,036.32 0.0114 0.1923 06/30/2026
6 Baillie Gifford & Co. 592,380 -290,192 56,773,699.2 0.0322 0.2464 06/30/2026
7 Jane Street Capital LLC 128,490 -208,267 12,314,481.6 0.0072 0.0535 06/30/2026
8 Longaeva Partners LP 0 -119,204 0 0 0
9 BofA Securities, Inc. 16,548 -88,267 1,585,960.32 0.0023 0.0069 06/30/2026
10 Group One Trading LLC 21,540 -82,408 2,064,393.6 0.0627 0.009 06/30/2026

Data provided by FactSet Research Systems Inc.