# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 T. Rowe Price Investment Management, Inc. 5,856,073 1,022,431 530,208,849.42 0.328 2.436 03/31/2026
2 Fidelity Management & Research Co. LLC 5,215,072 328,477 472,172,618.88 0.0236 2.1694 03/31/2026
3 PRIMECAP Management Co. 3,793,711 -77,055 343,482,593.94 0.2094 1.5781 03/31/2026
4 Flossbach von Storch SE 3,680,315 -549,718 333,215,720.1 0.8368 1.531 03/31/2026
5 Dodge & Cox 3,676,791 29,700 332,896,657.14 0.1298 1.5295 03/31/2026
6 BNP Paribas Financial Markets 1,651,789 548,491 149,552,976.06 0.0825 0.6871 03/31/2026
7 Temasek Holdings Pte Ltd. (Investment Management) 1,506,027 0 136,355,684.58 0.3016 0.6265 03/31/2026
8 Baillie Gifford & Co. 882,572 -6,996,787 79,908,068.88 0.0489 0.3671 03/31/2026
9 First Trust Advisors LP 839,991 534,369 76,052,785.14 0.0433 0.3494 03/31/2026
10 Bank of America, NA (Private Banking) 784,887 257,497 71,063,668.98 0.0194 0.3265 03/31/2026
11 Citadel Advisors LLC 783,173 474,189 70,908,483.42 0.0642 0.3258 03/31/2026
12 BlackRock Fund Advisors 712,840 297,960 64,540,533.6 0.0012 0.2965 03/31/2026
13 ACATIS Investment Kapitalverwaltungsgesellschaft mbH 668,254 170,418 60,503,717.16 0.9541 0.278 03/31/2026
14 Massachusetts Financial Services Co. 644,738 644,738 58,374,578.52 0.0184 0.2682 03/31/2026
15 Long Focus Capital Management LLC 624,000 226,345 56,496,960 2.2544 0.2596 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Fidelity Contrafund 2,550,522 1,407,111 230,924,261.88 0.1338 1.061 04/30/2026
2 Dodge & Cox International Stock Fund 2,517,713 0 227,953,735.02 0.3423 1.0473 03/31/2026
3 Flossbach von Storch - Multiple Opportunities 2,426,536 -300,000 219,698,569.44 0.9698 1.0094 03/31/2026
4 T. Rowe Price Capital Appreciation Fund 2,272,437 555,465 205,746,445.98 0.4229 0.9453 03/31/2026
5 Vanguard Capital Opportunity Fund 2,189,120 -24,620 198,202,924.8 0.6459 0.9106 03/31/2026
6 T Rowe Price Mid Cap Growth Fund 1,019,300 -2,300 92,287,422 0.384 0.424 03/31/2026
7 Fidelity Contrafund Commingled Pool 989,672 553,328 89,604,902.88 0.1392 0.4117 04/30/2026
8 Flossbach von Storch - Multiple Opportunities II 975,000 -231,959 88,276,500 0.9218 0.4056 03/31/2026
9 PRIMECAP Odyssey Aggressive Growth Fund 919,146 -17,430 83,219,478.84 1.0791 0.3824 03/31/2026
10 First Trust NYSE Arca Biotechnology Index Fund 808,873 433,125 73,235,361.42 2.8078 0.3365 05/29/2026
11 Deka - GlobalChampions 600,000 0 54,324,000 0.3387 0.2496 11/30/2025
12 iShares Biotechnology ETF 583,855 122,060 52,862,231.7 0.6722 0.2429 05/29/2026
13 Fidelity Contrafund K6 558,288 316,143 50,547,395.52 0.138 0.2322 04/30/2026
14 Fidelity Emerging Markets Fund 546,500 166,600 49,480,110 0.4358 0.2273 04/30/2026
15 Dodge & Cox Global Stock Fund 525,778 -13,500 47,603,940.12 0.3692 0.2187 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 T. Rowe Price Investment Management, Inc. 5,856,073 1,022,431 530,208,849.42 0.328 2.436 03/31/2026
2 Massachusetts Financial Services Co. 644,738 644,738 58,374,578.52 0.0184 0.2682 03/31/2026
3 BNP Paribas Financial Markets 1,651,789 548,491 149,552,976.06 0.0825 0.6871 03/31/2026
4 First Trust Advisors LP 839,991 534,369 76,052,785.14 0.0433 0.3494 03/31/2026
5 Citadel Advisors LLC 783,173 474,189 70,908,483.42 0.0642 0.3258 03/31/2026
6 BlackRock Investment Management (UK) Ltd. 601,399 402,358 54,450,665.46 0.0062 0.2502 03/31/2026
7 UBS Asset Management Switzerland AG 389,899 389,899 35,301,455.46 0.0093 0.1622 03/31/2026
8 UBS Asset Management (Americas) LLC 380,596 380,596 34,459,161.84 0.0169 0.1583 03/31/2026
9 Fidelity Management & Research Co. LLC 5,215,072 328,477 472,172,618.88 0.0236 2.1694 03/31/2026
10 Voloridge Investment Management LLC 307,864 307,864 27,874,006.56 0.0991 0.1281 03/31/2026
# Holder Name Position Position Change $ Market Value % Port % O/S Rpt Date
1 Baillie Gifford & Co. 882,572 -6,996,787 79,908,068.88 0.0489 0.3671 03/31/2026
2 Capital Research & Management Co. (International Investors) 0 -1,135,066 0 0 0
3 Flossbach von Storch SE 3,680,315 -549,718 333,215,720.1 0.8368 1.531 03/31/2026
4 UBS Securities LLC 111,172 -305,212 10,065,512.88 0.0036 0.0462 03/31/2026
5 Capital International, Inc. 0 -293,208 0 0 0
6 Franklin Templeton Institutional LLC 375,960 -292,270 34,039,418.4 1.8407 0.1564 03/31/2026
7 abrdn, Inc. 0 -291,907 0 0 0
8 Newton Investment Management North America LLC 0 -278,527 0 0 0
9 Baker Bros. Advisors LP 119,743 -249,180 10,841,531.22 0.0541 0.0498 03/31/2026
10 The Bank of New York Mellon Corp. (Investment Management) 18,807 -244,498 1,702,785.78 0.0007 0.0078 03/31/2026

Data provided by FactSet Research Systems Inc.