| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 7,991,377 | 7,991,377 | 31,166,370.3 | 0.0148 | 6.9418 | 09/30/2025 |
| 2 | HHLR Advisors Ltd. | 5,980,568 | 0 | 23,324,215.2 | 0.169 | 5.1951 | 09/30/2025 |
| 3 | Adage Capital Management LP | 3,338,034 | 3,338,034 | 13,018,332.6 | 0.02 | 2.8996 | 09/30/2025 |
| 4 | Morgan Stanley & Co. LLC | 2,232,040 | 2,197,223 | 8,704,956 | 0.003 | 1.9389 | 09/30/2025 |
| 5 | Ariose Capital Management Ltd. | 1,704,393 | 1,704,393 | 6,647,132.7 | 2.1455 | 1.4805 | 09/30/2025 |
| 6 | Exome Asset Management LLC | 1,439,604 | 1,439,604 | 5,614,455.6 | 2.7024 | 1.2505 | 09/30/2025 |
| 7 | Candriam Belgium SA | 1,132,563 | 1,132,563 | 4,416,995.7 | 0.0119 | 0.9838 | 09/30/2025 |
| 8 | Woodline Partners LP | 1,050,000 | 1,050,000 | 4,095,000 | 0.0186 | 0.9121 | 09/30/2025 |
| 9 | Point72 Asset Management LP | 638,714 | 638,714 | 2,490,984.6 | 0.0047 | 0.5548 | 09/30/2025 |
| 10 | SG Americas Securities LLC | 463,894 | -358,147 | 1,809,186.6 | 0.0065 | 0.403 | 09/30/2025 |
| 11 | Barclays Bank Plc (Private Banking) | 395,431 | 365,061 | 1,542,180.9 | 0.0003 | 0.3435 | 09/30/2025 |
| 12 | SSgA Funds Management, Inc. | 337,400 | 337,400 | 1,315,860 | 0 | 0.2931 | 09/30/2025 |
| 13 | UBS Securities LLC | 295,078 | -23,468 | 1,150,804.2 | 0.0005 | 0.2563 | 09/30/2025 |
| 14 | Abaris Investment Management AG | 224,000 | -58,000 | 873,600 | 2.1223 | 0.1946 | 06/30/2025 |
| 15 | Goldman Sachs & Co. LLC (Private Banking) | 218,470 | 207,785 | 852,033 | 0.0004 | 0.1898 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | SPDR Portfolio Emerging Markets ETF | 272,672 | 272,672 | 1,063,420.8 | 0.0074 | 0.2369 | 10/31/2025 |
| 2 | Abaris Emerging Markets Equity | 124,000 | 0 | 483,600 | 4.2429 | 0.1077 | 04/30/2024 |
| 3 | ALPS Barrons 400 ETF | 111,490 | 111,490 | 434,811 | 0.2387 | 0.0968 | 10/31/2025 |
| 4 | Abaris Biotechnology Opportunities | 100,000 | 0 | 390,000 | 1.5737 | 0.0869 | 06/30/2025 |
| 5 | Fidelity Nasdaq Composite Index Fund | 54,562 | 32,525 | 212,791.8 | 0.0009 | 0.0474 | 09/30/2025 |
| 6 | SPDR S&P Emerging Markets Small Cap ETF | 52,900 | 52,900 | 206,310 | 0.0292 | 0.046 | 10/31/2025 |
| 7 | DFA Emerging Markets Social Core Equity Portfolio | 18,909 | 0 | 73,745.1 | 0.0039 | 0.0164 | 08/31/2025 |
| 8 | DFA Emerging Markets Core Equity 2 Portfolio | 16,217 | 16,217 | 63,246.3 | 0.0002 | 0.0141 | 08/31/2025 |
| 9 | Dimensional Funds II Plc - Emerging Markets Targeted Value Fd. | 14,503 | -518 | 56,561.7 | 0.0086 | 0.0126 | 05/31/2025 |
| 10 | SPDR S&P China ETF | 13,500 | 13,500 | 52,650 | 0.011 | 0.0117 | 10/31/2025 |
| 11 | DFA Emerging Markets Sustainability Core 1 Portfolio | 9,306 | 0 | 36,293.4 | 0.003 | 0.0081 | 08/31/2025 |
| 12 | ActivePassive International Equity ETF | 8,172 | 8,172 | 31,870.8 | 0.0034 | 0.0071 | 10/31/2025 |
| 13 | Dimensional Emerging Markets Sustainability Trust | 6,531 | 6,531 | 25,470.9 | 0.0063 | 0.0057 | 10/31/2025 |
| 14 | Dimensional Funds Plc - World Equity Fund | 5,937 | 5,937 | 23,154.3 | 0.0004 | 0.0052 | 09/30/2025 |
| 15 | DFA World (ex-US) Core Equity Portfolio | 4,515 | 0 | 17,608.5 | 0.0004 | 0.0039 | 08/31/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Janus Henderson Investors US LLC | 7,991,377 | 7,991,377 | 31,166,370.3 | 0.0148 | 6.9418 | 09/30/2025 |
| 2 | Adage Capital Management LP | 3,338,034 | 3,338,034 | 13,018,332.6 | 0.02 | 2.8996 | 09/30/2025 |
| 3 | Morgan Stanley & Co. LLC | 2,232,040 | 2,197,223 | 8,704,956 | 0.003 | 1.9389 | 09/30/2025 |
| 4 | Ariose Capital Management Ltd. | 1,704,393 | 1,704,393 | 6,647,132.7 | 2.1455 | 1.4805 | 09/30/2025 |
| 5 | Exome Asset Management LLC | 1,439,604 | 1,439,604 | 5,614,455.6 | 2.7024 | 1.2505 | 09/30/2025 |
| 6 | Candriam Belgium SA | 1,132,563 | 1,132,563 | 4,416,995.7 | 0.0119 | 0.9838 | 09/30/2025 |
| 7 | Woodline Partners LP | 1,050,000 | 1,050,000 | 4,095,000 | 0.0186 | 0.9121 | 09/30/2025 |
| 8 | Point72 Asset Management LP | 638,714 | 638,714 | 2,490,984.6 | 0.0047 | 0.5548 | 09/30/2025 |
| 9 | Barclays Bank Plc (Private Banking) | 395,431 | 365,061 | 1,542,180.9 | 0.0003 | 0.3435 | 09/30/2025 |
| 10 | SSgA Funds Management, Inc. | 337,400 | 337,400 | 1,315,860 | 0 | 0.2931 | 09/30/2025 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Stonepine Capital Management LLC | 0 | -483,647 | 0 | 0 | 0 | |
| 2 | Two Sigma Advisers LP | 0 | -363,200 | 0 | 0 | 0 | |
| 3 | SG Americas Securities LLC | 463,894 | -358,147 | 1,809,186.6 | 0.0065 | 0.403 | 09/30/2025 |
| 4 | Two Sigma Investments LP | 0 | -210,366 | 0 | 0 | 0 | |
| 5 | abrdn, Inc. | 43,738 | -118,842 | 170,578.2 | 0.0016 | 0.038 | 09/30/2025 |
| 6 | Alberta Investment Management Corp. | 0 | -74,723 | 0 | 0 | 0 | |
| 7 | Ground Swell Capital LLC | 0 | -63,730 | 0 | 0 | 0 | |
| 8 | Abaris Investment Management AG | 224,000 | -58,000 | 873,600 | 2.1223 | 0.1946 | 06/30/2025 |
| 9 | HBK Sorce Advisory LLC | 0 | -46,060 | 0 | 0 | 0 | |
| 10 | Millennium Management LLC | 22,453 | -39,025 | 87,566.7 | 0.0001 | 0.0195 | 09/30/2025 |
Data provided by FactSet Research Systems Inc.