| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 4,974,906 | 4,974,906 | 19,153,388.1 | 1.094 | 2.3803 | 03/31/2026 |
| 2 | Paradigm BioCapital Advisors LP | 4,000,000 | 4,000,000 | 15,400,000 | 0.3442 | 1.9138 | 03/31/2026 |
| 3 | Millennium Management LLC | 2,987,613 | 2,875,583 | 11,502,310.05 | 0.0079 | 1.4294 | 03/31/2026 |
| 4 | Trails Edge Capital Partners LP | 2,657,997 | 2,657,997 | 10,233,288.45 | 2.2186 | 1.2717 | 03/31/2026 |
| 5 | Franklin Advisers, Inc. | 2,461,565 | 2,461,565 | 9,477,025.25 | 0.0042 | 1.1777 | 03/31/2026 |
| 6 | UBS Securities LLC | 2,300,256 | 2,300,074 | 8,855,985.6 | 0.0032 | 1.1006 | 03/31/2026 |
| 7 | Adar1 Capital Management LLC | 2,174,398 | 2,174,398 | 8,371,432.3 | 0.5023 | 1.0403 | 03/31/2026 |
| 8 | Polar Capital LLP | 2,132,138 | 2,132,138 | 8,208,731.3 | 0.0161 | 1.0201 | 03/31/2026 |
| 9 | Boothbay Fund Management LLC | 1,470,407 | 1,470,407 | 5,661,066.95 | 0.1183 | 0.7035 | 03/31/2026 |
| 10 | Ikarian Capital LLC | 1,429,101 | 1,429,101 | 5,502,038.85 | 0.9049 | 0.6838 | 03/31/2026 |
| 11 | NEXTBio Capital Management LP | 1,333,484 | 1,333,484 | 5,133,913.4 | 2.9574 | 0.638 | 03/31/2026 |
| 12 | RTW Investments LP | 1,298,702 | 1,298,702 | 5,000,002.7 | 0.0473 | 0.6214 | 03/31/2026 |
| 13 | Deep Track Capital LP | 1,222,453 | 1,222,453 | 4,706,444.05 | 0.083 | 0.5849 | 03/31/2026 |
| 14 | Point72 Asset Management LP | 956,221 | 956,221 | 3,681,450.85 | 0.0054 | 0.4575 | 03/31/2026 |
| 15 | Columbia Management Investment Advisers LLC | 844,215 | 844,215 | 3,250,227.75 | 0.0007 | 0.4039 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Polar Capital Funds Plc - Biotechnology Fund | 2,024,543 | 134,543 | 7,794,490.55 | 0.2457 | 0.9686 | 04/30/2026 |
| 2 | FTIF SICAV - Biotechnology Discovery Fund | 1,672,877 | 80,877 | 6,440,576.45 | 0.3673 | 0.8004 | 04/30/2026 |
| 3 | Franklin Biotechnology Discovery Fund | 969,588 | 61,588 | 3,732,913.8 | 0.3583 | 0.4639 | 04/30/2026 |
| 4 | Fidelity Advisor Series VII - Biotechnology Fund | 685,400 | 685,400 | 2,638,790 | 0.1389 | 0.3279 | 04/30/2026 |
| 5 | Simplify Propel Opportunities ETF | 227,923 | -109,739 | 877,503.55 | 1.191 | 0.1091 | 05/29/2026 |
| 6 | Artisan International Small-Mid Fund | 195,745 | 195,745 | 753,618.25 | 0.0267 | 0.0937 | 03/31/2026 |
| 7 | Fidelity Nasdaq Composite Index Fund | 34,355 | 29,660 | 132,266.75 | 0.0005 | 0.0164 | 04/30/2026 |
| 8 | Russell Investment Funds - Investment US Small Cap Equity Fund | 9,220 | 9,220 | 35,497 | 0.0147 | 0.0044 | 03/31/2026 |
| 9 | ActivePassive International Equity ETF | 8,145 | 8,145 | 31,358.25 | 0.003 | 0.0039 | 05/29/2026 |
| 10 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 2,821 | 2,821 | 10,860.85 | 0.0309 | 0.0013 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 4,974,906 | 4,974,906 | 19,153,388.1 | 1.094 | 2.3803 | 03/31/2026 |
| 2 | Paradigm BioCapital Advisors LP | 4,000,000 | 4,000,000 | 15,400,000 | 0.3442 | 1.9138 | 03/31/2026 |
| 3 | Millennium Management LLC | 2,987,613 | 2,875,583 | 11,502,310.05 | 0.0079 | 1.4294 | 03/31/2026 |
| 4 | Trails Edge Capital Partners LP | 2,657,997 | 2,657,997 | 10,233,288.45 | 2.2186 | 1.2717 | 03/31/2026 |
| 5 | Franklin Advisers, Inc. | 2,461,565 | 2,461,565 | 9,477,025.25 | 0.0042 | 1.1777 | 03/31/2026 |
| 6 | UBS Securities LLC | 2,300,256 | 2,300,074 | 8,855,985.6 | 0.0032 | 1.1006 | 03/31/2026 |
| 7 | Adar1 Capital Management LLC | 2,174,398 | 2,174,398 | 8,371,432.3 | 0.5023 | 1.0403 | 03/31/2026 |
| 8 | Polar Capital LLP | 2,132,138 | 2,132,138 | 8,208,731.3 | 0.0161 | 1.0201 | 03/31/2026 |
| 9 | Boothbay Fund Management LLC | 1,470,407 | 1,470,407 | 5,661,066.95 | 0.1183 | 0.7035 | 03/31/2026 |
| 10 | Ikarian Capital LLC | 1,429,101 | 1,429,101 | 5,502,038.85 | 0.9049 | 0.6838 | 03/31/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Yiheng Capital Management LP | 0 | -2,644,926 | 0 | 0 | 0 | |
| 2 | StemPoint Capital LP | 0 | -30,824 | 0 | 0 | 0 | |
| 3 | AQR Capital Management LLC | 0 | -10,000 | 0 | 0 | 0 | |
| 4 | Creative Planning LLC | 0 | -10,000 | 0 | 0 | 0 | |
| 5 | Morgan Stanley Smith Barney LLC (Investment Management) | 0 | -1,080 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.