| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 8,163,191 | 3,188,285 | 25,469,155.92 | 1.6292 | 3.4549 | 06/30/2026 |
| 2 | Paradigm BioCapital Advisors LP | 4,000,000 | 0 | 12,480,000 | 0.2823 | 1.6929 | 06/30/2026 |
| 3 | Adar1 Capital Management LLC | 3,606,656 | 1,432,258 | 11,252,766.72 | 0.6157 | 1.5264 | 06/30/2026 |
| 4 | Millennium Management LLC | 3,512,174 | 524,561 | 10,957,982.88 | 0.0076 | 1.4864 | 06/30/2026 |
| 5 | Nantahala Capital Management LLC | 2,686,393 | 2,686,393 | 8,381,546.16 | 0.5217 | 1.137 | 06/30/2026 |
| 6 | Trails Edge Capital Partners LP | 2,657,997 | 0 | 8,292,950.64 | 1.4701 | 1.1249 | 06/30/2026 |
| 7 | Franklin Advisers, Inc. | 2,642,611 | 181,046 | 8,244,946.32 | 0.0035 | 1.1184 | 06/30/2026 |
| 8 | Squadron Capital Management LLC | 2,435,000 | 1,900,000 | 7,597,200 | 3.0801 | 1.0306 | 06/30/2026 |
| 9 | Woodline Partners LP | 2,323,149 | 2,323,149 | 7,248,224.88 | 0.0225 | 0.9832 | 06/30/2026 |
| 10 | abrdn, Inc. | 2,307,773 | 2,307,773 | 7,200,251.76 | 0.0664 | 0.9767 | 06/30/2026 |
| 11 | UBS Securities LLC | 2,284,905 | -15,351 | 7,128,903.6 | 0.0027 | 0.967 | 06/30/2026 |
| 12 | Boothbay Fund Management LLC | 2,003,782 | 533,375 | 6,251,799.84 | 0.1285 | 0.8481 | 06/30/2026 |
| 13 | NEXTBio Capital Management LP | 1,787,984 | 454,500 | 5,578,510.08 | 2.803 | 0.7567 | 06/30/2026 |
| 14 | Columbia Management Investment Advisers LLC | 1,697,148 | 852,933 | 5,295,101.76 | 0.0011 | 0.7183 | 06/30/2026 |
| 15 | Point72 Asset Management LP | 1,683,012 | 726,791 | 5,250,997.44 | 0.0083 | 0.7123 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FTIF SICAV - Biotechnology Discovery Fund | 1,929,112 | 375,688 | 6,018,829.44 | 0.3133 | 0.8165 | 08/31/2026 |
| 2 | abrdn World Healthcare Fund | 1,380,877 | 1,380,877 | 4,308,336.24 | 0.7278 | 0.5844 | 08/31/2026 |
| 3 | abrdn Life Sciences Investors | 1,093,492 | 1,093,492 | 3,411,695.04 | 0.6074 | 0.4628 | 06/30/2026 |
| 4 | Franklin Biotechnology Discovery Fund | 1,042,549 | 134,549 | 3,252,752.88 | 0.3048 | 0.4412 | 08/31/2026 |
| 5 | Fidelity Advisor Series VII - Biotechnology Fund | 685,400 | 685,400 | 2,138,448 | 0.0938 | 0.2901 | 08/31/2026 |
| 6 | Helium Fund - Selection | 589,277 | 589,277 | 1,838,544.24 | 0.1024 | 0.2494 | 06/30/2026 |
| 7 | FIAM Small Capitalization Core Commingled Pool | 474,345 | 474,345 | 1,479,956.4 | 0.0338 | 0.2008 | 07/31/2026 |
| 8 | Simplify Propel Opportunities ETF | 313,483 | 85,560 | 978,066.96 | 8.8125 | 0.1327 | 09/30/2026 |
| 9 | Strategic Advisers Fidelity US Total Stock Fund | 220,400 | 220,400 | 687,648 | 0.0003 | 0.0933 | 08/31/2026 |
| 10 | Helium Fund - Performance | 184,714 | 184,714 | 576,307.68 | 0.046 | 0.0782 | 06/30/2026 |
| 11 | Fidelity Small Cap Stock Fund | 154,400 | 154,400 | 481,728 | 0.0375 | 0.0653 | 07/31/2026 |
| 12 | Artisan International Small-Mid Fund | 144,292 | -51,453 | 450,191.04 | 0.017 | 0.0611 | 06/30/2026 |
| 13 | Fidelity Series Small Cap Core Fund | 136,161 | 136,161 | 424,822.32 | 0.0286 | 0.0576 | 07/31/2026 |
| 14 | Helium Fund - Helium Fund | 52,527 | 52,527 | 163,884.24 | 0.0234 | 0.0222 | 06/30/2026 |
| 15 | Blackstone Alternative Multi Strategy Fund | 42,752 | 42,752 | 133,386.24 | 0.0084 | 0.0181 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 8,163,191 | 3,188,285 | 25,469,155.92 | 1.6292 | 3.4549 | 06/30/2026 |
| 2 | Nantahala Capital Management LLC | 2,686,393 | 2,686,393 | 8,381,546.16 | 0.5217 | 1.137 | 06/30/2026 |
| 3 | Woodline Partners LP | 2,323,149 | 2,323,149 | 7,248,224.88 | 0.0225 | 0.9832 | 06/30/2026 |
| 4 | abrdn, Inc. | 2,307,773 | 2,307,773 | 7,200,251.76 | 0.0664 | 0.9767 | 06/30/2026 |
| 5 | Squadron Capital Management LLC | 2,435,000 | 1,900,000 | 7,597,200 | 3.0801 | 1.0306 | 06/30/2026 |
| 6 | Citadel Advisors LLC | 1,540,000 | 1,540,000 | 4,804,800 | 0.0036 | 0.6518 | 06/30/2026 |
| 7 | Adar1 Capital Management LLC | 3,606,656 | 1,432,258 | 11,252,766.72 | 0.6157 | 1.5264 | 06/30/2026 |
| 8 | StemPoint Capital LP | 1,426,320 | 1,426,320 | 4,450,118.4 | 0.9497 | 0.6037 | 06/30/2026 |
| 9 | JPMorgan Securities LLC (Investment Management) | 1,309,100 | 1,309,100 | 4,084,392 | 0.0019 | 0.554 | 06/30/2026 |
| 10 | Kingdon Capital Management LLC | 1,270,000 | 1,270,000 | 3,962,400 | 0.5734 | 0.5375 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 0 | -1,298,702 | 0 | 0 | 0 | |
| 2 | Polar Capital LLP | 1,074,214 | -1,057,924 | 3,351,547.68 | 0.0064 | 0.4546 | 06/30/2026 |
| 3 | Deep Track Capital LP | 800,000 | -422,453 | 2,496,000 | 0.041 | 0.3386 | 06/30/2026 |
| 4 | Ikarian Capital LLC | 1,129,101 | -300,000 | 3,522,795.12 | 0.655 | 0.4779 | 06/30/2026 |
| 5 | Russell Investment Management LLC | 0 | -205,639 | 0 | 0 | 0 | |
| 6 | Artisan Partners LP | 263,538 | -59,468 | 822,238.56 | 0.0007 | 0.1115 | 06/30/2026 |
| 7 | Prelude Capital Management LLC | 0 | -40,000 | 0 | 0 | 0 | |
| 8 | ExodusPoint Capital Management LP | 0 | -38,256 | 0 | 0 | 0 | |
| 9 | Hudson Bay Capital Management LP | 115,000 | -30,459 | 358,800 | 0.0017 | 0.0487 | 06/30/2026 |
| 10 | Virtu Americas LLC | 0 | -18,729 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.