| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 8,163,191 | 6,163,191 | 39,999,635.9 | 1.8871 | 3.4549 | 06/30/2026 |
| 2 | Paradigm BioCapital Advisors LP | 4,000,000 | 0 | 19,600,000 | 0.392 | 1.6929 | 06/30/2026 |
| 3 | Adar1 Capital Management LLC | 3,606,656 | 896,810 | 17,672,614.4 | 0.7665 | 1.5264 | 06/30/2026 |
| 4 | Millennium Management LLC | 3,512,174 | 859,604 | 17,209,652.6 | 0.0115 | 1.4864 | 06/30/2026 |
| 5 | Nantahala Capital Management LLC | 2,686,393 | 2,686,393 | 13,163,325.7 | 0.7332 | 1.137 | 06/30/2026 |
| 6 | Trails Edge Capital Partners LP | 2,657,997 | 0 | 13,024,185.3 | 1.7276 | 1.1249 | 06/30/2026 |
| 7 | Franklin Advisers, Inc. | 2,642,611 | 142,470 | 12,948,793.9 | 0.0055 | 1.1184 | 06/30/2026 |
| 8 | Squadron Capital Management LLC | 2,435,000 | 2,135,000 | 11,931,500 | 4.1285 | 1.0306 | 06/30/2026 |
| 9 | Woodline Partners LP | 2,323,149 | 2,323,149 | 11,383,430.1 | 0.034 | 0.9832 | 06/30/2026 |
| 10 | abrdn, Inc. | 2,307,773 | 2,307,773 | 11,308,087.7 | 0.0981 | 0.9767 | 06/30/2026 |
| 11 | UBS Securities LLC | 2,284,905 | -349,857 | 11,196,034.5 | 0.0041 | 0.967 | 06/30/2026 |
| 12 | Boothbay Fund Management LLC | 2,003,782 | 1,344,811 | 9,818,531.8 | 0.1898 | 0.8481 | 06/30/2026 |
| 13 | NEXTBio Capital Management LP | 1,787,984 | 489,283 | 8,761,121.6 | 3.5916 | 0.7567 | 06/30/2026 |
| 14 | Columbia Management Investment Advisers LLC | 1,697,148 | 1,081,675 | 8,316,025.2 | 0.0017 | 0.7183 | 06/30/2026 |
| 15 | Point72 Asset Management LP | 1,683,012 | 1,683,012 | 8,246,758.8 | 0.0126 | 0.7123 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | FTIF SICAV - Biotechnology Discovery Fund | 1,672,877 | 80,877 | 8,197,097.3 | 0.379 | 0.708 | 06/30/2026 |
| 2 | abrdn World Healthcare Fund | 1,380,877 | 1,380,877 | 6,766,297.3 | 1.0289 | 0.5844 | 07/31/2026 |
| 3 | Polar Capital Funds Plc - Biotechnology Fund | 976,208 | -913,792 | 4,783,419.2 | 0.12 | 0.4132 | 06/30/2026 |
| 4 | Franklin Biotechnology Discovery Fund | 969,588 | 61,588 | 4,750,981.2 | 0.386 | 0.4104 | 06/30/2026 |
| 5 | Fidelity Advisor Series VII - Biotechnology Fund | 685,400 | 685,400 | 3,358,460 | 0.1383 | 0.2901 | 06/30/2026 |
| 6 | Simplify Propel Opportunities ETF | 313,483 | -24,179 | 1,536,066.7 | 1.8166 | 0.1327 | 07/31/2026 |
| 7 | Artisan International Small-Mid Fund | 144,292 | 144,292 | 707,030.8 | 0.026 | 0.0611 | 06/30/2026 |
| 8 | Fidelity Nasdaq Composite Index Fund | 34,355 | 29,660 | 168,339.5 | 0.0006 | 0.0145 | 06/30/2026 |
| 9 | Harbor Health Care ETF | 33,996 | 33,996 | 166,580.4 | 0.3796 | 0.0144 | 07/31/2026 |
| 10 | Harbor Health Care UCITS ETF | 11,822 | 11,822 | 57,927.8 | 0.3753 | 0.005 | 07/31/2026 |
| 11 | ActivePassive International Equity ETF | 10,009 | 10,009 | 49,044.1 | 0.0043 | 0.0042 | 07/31/2026 |
| 12 | Artisan Multiple Invt. Tr. - International Small-Mid Tr. | 2,073 | 2,073 | 10,157.7 | 0.0291 | 0.0009 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | Caligan Partners LP | 8,163,191 | 6,163,191 | 39,999,635.9 | 1.8871 | 3.4549 | 06/30/2026 |
| 2 | Nantahala Capital Management LLC | 2,686,393 | 2,686,393 | 13,163,325.7 | 0.7332 | 1.137 | 06/30/2026 |
| 3 | Woodline Partners LP | 2,323,149 | 2,323,149 | 11,383,430.1 | 0.034 | 0.9832 | 06/30/2026 |
| 4 | abrdn, Inc. | 2,307,773 | 2,307,773 | 11,308,087.7 | 0.0981 | 0.9767 | 06/30/2026 |
| 5 | Squadron Capital Management LLC | 2,435,000 | 2,135,000 | 11,931,500 | 4.1285 | 1.0306 | 06/30/2026 |
| 6 | Point72 Asset Management LP | 1,683,012 | 1,683,012 | 8,246,758.8 | 0.0126 | 0.7123 | 06/30/2026 |
| 7 | Citadel Advisors LLC | 1,540,000 | 1,540,000 | 7,546,000 | 0.0055 | 0.6518 | 06/30/2026 |
| 8 | Integral Health Asset Management LLC | 1,520,000 | 1,520,000 | 7,448,000 | 0.2915 | 0.6433 | 06/30/2026 |
| 9 | Boothbay Fund Management LLC | 2,003,782 | 1,344,811 | 9,818,531.8 | 0.1898 | 0.8481 | 06/30/2026 |
| 10 | JPMorgan Securities LLC (Investment Management) | 1,309,100 | 1,309,100 | 6,414,590 | 0.0029 | 0.554 | 06/30/2026 |
| # | Holder Name | Position | Position Change | $ Market Value | % Port | % O/S | Rpt Date |
|---|---|---|---|---|---|---|---|
| 1 | RTW Investments LP | 0 | -1,298,701 | 0 | 0 | 0 | |
| 2 | Polar Capital LLP | 1,074,214 | -924,666 | 5,263,648.6 | 0.0099 | 0.4546 | 06/30/2026 |
| 3 | UBS Securities LLC | 2,284,905 | -349,857 | 11,196,034.5 | 0.0041 | 0.967 | 06/30/2026 |
| 4 | Saturn V Capital Management LP | 0 | -283,166 | 0 | 0 | 0 | |
| 5 | Yiheng Capital Management LP | 0 | -255,915 | 0 | 0 | 0 | |
| 6 | Eventide Asset Management LLC | 0 | -250,000 | 0 | 0 | 0 | |
| 7 | Goldman Sachs & Co. LLC (Private Banking) | 224,499 | -205,096 | 1,100,045.1 | 0.0003 | 0.095 | 06/30/2026 |
| 8 | J. Goldman & Co. LP | 337,500 | -178,945 | 1,653,750 | 0.058 | 0.1428 | 06/30/2026 |
| 9 | Morgan Stanley & Co. LLC | 280,191 | -132,556 | 1,372,935.9 | 0.0004 | 0.1186 | 06/30/2026 |
| 10 | Superstring Capital Management LP | 0 | -100,000 | 0 | 0 | 0 |
Data provided by FactSet Research Systems Inc.